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Chenodeoxycholic Acid

Chenodeoxycholic Acid

Product Name: Chenodeoxycholic Acid 98%
Active ingredient: Chenodeoxycholic acid
Part Used: The Gall of Pig,Cow and Chicken
Specifications: 90%,97%,98%,99% HPLC
Melting point:165-167 °C
Appearance: White or yellowish crystalline powder
Test Methord: HPLC
CAS NO.: 474-25-9

Product Name: Chenodeoxycholic Acid 98%

Active ingredient: Chenodeoxycholic acid

Part Used: The Gall of Pig,Cow and Chicken

Specifications: 90%,97%,98%,99% HPLC

Melting point:165-167 °C

Appearance: White or yellowish crystalline powder

Test Methord: HPLC

CAS NO.: 474-25-9

Molecular Formula & Molecular Weight: C24H40O4  392.6


Description:

Chenodeoxycholic acid (also known as chenodesoxycholic acid and chenocholic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167 °C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the 4 main organic acids produced by the liver.


Chenodeoxycholic acid is synthesized in the liver from cholesterol. It was first isolated in the domestic goose, hence the 'cheno' portion of its name


This compound, when altered by bacteria in the colon, will result in conversion to its secondary bile acid known as lithocholic acid. Both of these bile acids, in addition to the others, can be conjugated to taurine or glycine. Conjugation, a function carried out by the liver will result in a lowered pKa and therefore, the compounds will remain ionized. These ionized compounds will stay in the gastrointestinal tract until reaching the ileum where they will be reabsorbed. The purpose of this conjugation is to keep the bile acids in the tract until the end to facilitate lipid digestion all the way to the ileum.


In cases where bacteria overgrow in the small intestine, often due to a blind loop in the intestine retaining chyme in one place, the bacteria will de-conjugate the bile acids and therefore impede fat digestion and absorption. This can lead to steatorrhea.


Chenodeoxycholic acid and cholic acid are the most important human bile acids. Some other mammals synthesize predominantly deoxycholic acid.


Application:

1.  It can be used for the prevention and treatment of cholesterol gallstones and hyperlipidemia, for courage primality stones and mixed stones have a certain effect. Mild symptoms, gallbladder function well, biliary obstruction in patients with no better effect. Long-term use of mild diarrhea, a small number of patients may have itching, dizziness, nausea and bloating, etc., individual patients may induce biliary colic and temporary elevated transaminase. Pregnant women, women of childbearing age, pancreatitis, cirrhosis of the liver, stomach and duodenal ulcer, hepatitis and biliary obstruction is disabled.

2.  For the dissolution of cholesterol gall-stone, effective against bile pigment stone or mixed calculus.

3.  It is mainly used ursodeoxycholic acid intermediates.


PACKAGE and STORAGE:

1. 1-5kg with double plastic container inside/aluminum foil bag outside. 10kg with double plastic container inside/carton outside. 25kg with double plastic container inside/fiber drum outside or it is at your option.

2. Stored in a cool & dry well-closed container, keep away from moisture and strong light/heat.

3. Shelf Life:Two years under well storage situation.

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SHIPPING:

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